a16z backed Facebook, Airbnb, Coinbase, Slack, GitHub, and Databricks before anyone knew their names. These are their current bets.

They just raised $15 billion — their largest fund ever. Their portfolio companies have produced some of the most consequential returns in venture capital history. Their judgment on what wins has been right for 15 years.

Every company below is in their portfolio — and actively hiring.

— Ashher

1. Cursor The AI code editor used by engineers at OpenAI, Stripe, and Spotify. a16z co-led the Series A and has backed every round since. Hit $1B in ARR faster than any SaaS company in history. 📍 SF / NYC | 💰 $3.4B total raised | 🔗 cursor.com/careers

2. Decagon AI customer support agents that fully resolve tickets end to end — no human handoff. Used by Hertz, Eventbrite, Rippling, Duolingo, and Substack. a16z backed from seed through Series C. $4.5B valuation as of January 2026. 📍 San Francisco | 💰 $481M total raised | 🔗 decagon.ai/careers

3. Databricks The data and AI platform running inside 60%+ of the Fortune 500. a16z backed the Series A in 2013 and has been in every round since. $4.8B revenue run rate. $134B valuation — the highest of any company on this list. 📍 SF / Remote | 💰 $5B Series L | 🔗 databricks.com/company/careers/open-positions

4. Abridge AI medical documentation deployed across 150+ health systems including Johns Hopkins, UCSF, and Mayo Clinic. Turns clinical conversations into structured notes in real time, giving physicians hours back each week. a16z co-led the $300M Series E alongside Khosla Ventures. 📍 Pittsburgh / Remote | 💰 $300M Series E | 🔗 jobs.ashbyhq.com/abridge

5. Ambience Healthcare AI platform for clinical documentation, coding, and workflow across 100+ specialties. Integrates directly with Epic, Oracle Cerner, and athenahealth. Ranked #1 for improving clinician experience in the KLAS Research Emerging Solutions Top 20. a16z co-led the $243M Series C alongside Oak HC/FT. 📍 San Francisco / Remote | 💰 $243M Series C | 🔗 jobs.ashbyhq.com/ambiencehealthcare

6. Thinking Machines Lab Frontier AI research company founded by Mira Murati, former CTO of OpenAI. a16z led the $2B seed round at a $12B valuation — one of the largest seed rounds ever raised. Strategic gigawatt-scale partnership with NVIDIA announced March 2026. 📍 SF / NYC | 💰 $2B seed | 🔗 job-boards.greenhouse.io/thinkingmachines

7. Flock Safety AI public safety platform deployed across 12,000+ public safety customers including cities, counties, and law enforcement agencies nationwide. a16z led the $275M Series F. Just opened a new Boston office with plans to add 150 jobs. 📍 Atlanta / Boston / Remote | 💰 $275M Series F | 🔗 flocksafety.com/careers

8. Replit AI development platform used by teams at 85% of Fortune 500 companies. Tripled its valuation to $9B in six months after the a16z-participated $400M round. Targeting $1B in revenue in 2026. 📍 SF / Remote | 💰 $400M | 🔗 replit.com/careers

9. Lio The world's first agentic AI procurement platform — automating 75% of procurement tasks end to end for enterprise. Already deployed at Walmart and Schaeffler. a16z led the $30M Series A in March 2026. 📍 Remote | 💰 $30M Series A | 🔗 jobs.ashbyhq.com/lio

10. Glimpse AI platform that automatically recovers cash from invalid retailer deductions for CPG brands — a problem that costs the industry billions annually. a16z led the $35M Series A in March 2026. 34%+ month-over-month revenue growth. 📍 Remote | 💰 $35M Series A | 🔗 jobs.ashbyhq.com/glimpse

11. Adaptive Security AI powered defense against social engineering — deepfakes, vishing, smishing, and AI-generated phishing at scale. a16z led the seed and participated in the $81M Series B alongside NVIDIA, Bain Capital, Capital One, and Citi. OpenAI's first ever cybersecurity investment. 500+ enterprise customers including PayPal, Figma, and Ramp. 📍 NYC / Remote | 💰 $81M Series B | 🔗 jobs.ashbyhq.com/adaptivesecurity

12. Mirelo AI generated sound effects and audio for video — building the audio layer the generative video world is missing. a16z and Index Ventures co-led the $41M seed in December 2025. Team of 10 with plans to double or triple headcount through 2026. 📍 Berlin / Remote | 💰 $41M seed | 🔗 jobs.ashbyhq.com/mirelo

13. Mind Robotics Industrial AI robotics spun out of Rivian by founder and CEO RJ Scaringe. Building full-stack robots for factory floors — dexterous, reasoning, and adaptable. a16z and Accel co-led the $500M Series A in March 2026, one of the largest Series A rounds in robotics history. $2B valuation. 📍 Palo Alto | 💰 $500M Series A | 🔗 jobs.ashbyhq.com/mindrobotics

14. EliseAI AI agents for housing and healthcare — automating leasing, maintenance requests, patient intake, and appointment scheduling end to end. a16z led the $250M Series E. Powers 10% of the entire US apartment market today. 📍 NYC / SF / Boston / Chicago | 💰 $250M Series E | 🔗 eliseai.com/careers

15. Substack The creator economy publishing platform that reached unicorn status in 2025. a16z has backed three rounds. 35M+ paid subscriptions across 250M monthly readers. 📍 SF / Remote | 💰 Unicorn 2025 | 🔗 substack.com/jobs

16. Hippocratic AI Patient facing AI agents for healthcare — handling pre-op calls, remote patient monitoring, appointment preparation, and chronic care management at scale. a16z backed from seed and participated in every subsequent round. $404M total raised. 50+ health system partners. 📍 Palo Alto / Remote | 💰 $404M total raised | 🔗 hippocraticai.com/careers

17. Sphere The world's first AI-native global tax compliance engine — handling sales tax, VAT, and GST across every jurisdiction automatically. a16z led the $21M Series A in November 2025. Used by ElevenLabs, Replit, Lovable, and Windsurf. Deploys in under 24 hours. 📍 San Francisco | 💰 $21M Series A | 🔗 jobs.ashbyhq.com/sphere

18. Periodic Labs AI scientists paired with autonomous physical labs — machines that hypothesize, run real experiments, and discover new superconductors and semiconductors at speeds no human team can match. a16z led the $300M seed in September 2025. Founded by Liam Fedus, former VP of Research at OpenAI, and Ekin Dogus Cubuk, former research scientist at Google DeepMind. Backed by Jeff Bezos, Eric Schmidt, Jeff Dean, and NVIDIA. 📍 San Francisco | 💰 $300M seed | 🔗 jobs.ashbyhq.com/periodic-labs

List verified March 2026. Job postings change fast — check each careers page directly for current openings.

Written by Ashher

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Austin Texas, United States